TABLE 2

Number, type, and rates per generation (±SD) of genome rearrangement in strains derived from in vitro and in vivo experiments

In vivo experimentIn vitro experiment
Type of eventsNo. of eventsRateaNo. of eventsRatea
GAL11.7 × 10−46.0 × 10−6
(±2.2 × 10−4)(±2.0 × 10−6)
SNP LOH163.3 × 10−473.5 × 10−4
(±5.8 × 10−4)(±2.4 × 10−5)
BIR100
Whole chromosomes500
All chromosomes61.2 × 10−300
(±4.2 × 10−3)
  • Standard deviation was calculated across loci (short-range LOH) or across strains (chromosome-level rates).

  • a GAL1 LOH rates were calculated as events per generation, SNP LOH rates were calculated as events per locus per generation, and chromosomal rates were calculated as events per chromosome per generation.