TABLE 3

Fold change in pigment values resulting from suppression of variegation by HMT mutations

Chromosomal locationFold change (± SD)
ReporterdSETDB1KDSu(var)3-906/+
118E-28X, pericentric7.8 ± 0.93.7 ± 0.1
39C-22L, pericentric6.6 ± 0.72.3 ± 0.5
118E-104, pericentric7.5 ± 1.02.0 ± 0.2
39C-124, arm8.6 ± 0.8−2.6 ± 0.1
118E-25-54, arm9.7 ± 0.2−2.3 ± 0.1
  • PEV modification by HMT mutations. Fold change in pigmentation in dominant modification assays upon knockdown of dSETDB1 expression (5–25% transcript quantities relative to wild type; dSETDB1hp2101B driven by daGAL4) or with the Su(var)3-906 allele (dominant effect). Mean fold change from the parental pigmentation is indicated with standard deviation from the mean; negative values indicate fold enhancement of PEV.