TABLE 7

Estimating θ in the presence of biased amplification

Xpe = 0.0pe = 0.01pe = 0.05pe = 0.1pe = 0.15
16×100.1 (14.4)100.0 (14.7)101.8 (15.2)102.4 (15.1)102.6 (15.6)
100.1 (14.4)100.1 (15.4)101.9 (15.5)102.3 (15.4)103.0 (15.9)
100.2 (14.9)101.5 (15.6)102.8 (16.5)100.6 (15.8)103.7 (15.9)
99.6 (15.7)103.7 (16.3)105.1 (16.7)105.6 (16.5)107.3 (18.7)
  • Here we set θ0 (the generating value of θ) = 100 and use ρ0 = 20. pe is the probability that a minor allele is not sequenced. We report the mean (and RMSE) of the estimates over 1000 simulations.