TABLE 5

Groups of functionally related genes among cdc13-1 interactors

GroupFunction of related genesSuppressorsUP–DOWNSynthetic
1DNA repair/DNA damage checkpoint/telomeresMLH2, MPH1, CHK1, DDC1, EXO1, RAD17, RAD24, RAD9, DOA1CHK1,a DDC1,a RAD17,a RAD24,a RAD9,a MRC1, RAD14, RAD4, RAD27, RAD52, YKU70, YKU80, ELG1, DOA1,a HPR5, MMS1, IMP2
2Protein degradationUBP3, UBP6, UBX4, UBX7, UFD2, DOA1, UBC4, SAN1, VID28, POC4PRE9
3Nonsense-mediated decayNMD4, NAM7, UPF3, EBS1, NMD2
4Chromatin architecture/silencing/histone modificationSCS2, SPT2, NPT1, SAS4, RIF2[SAS2, SAS4;a SAS complex], [SWD1, SWD3, BRE2; COMPASS complex], [CDC73, LEO1; Paf1 complex], DOT1, SIR1, RLF2, LGE1[SWC5, HTZ1; SWR1 complex]
5Vesicular transportPEX13, PEX15, PEX22, PEX3, PEX4, VAM6, VAM7, YPT6, YPT7, VPS1, VPS30, VPS35, VPS51, VPS60, DID2, SRN2, HSE1, PIB2, RIC1, VPS21, VPS8, SWA2, SSH1, SNC2, GOS1[MNN11, HOC1; golgi mannosyl transferase complex], ERV14, SEC66, TLG2, RUD3, GSG1, SRO7, SRN2aCCZ1, PBI2,b VPS4
6Casein kinase 2CKA1, CKA2, CKB2
7Ribosome functionRPL13A, RPL14A, RPL19A, RPL21B, RPL2A, RPL31B, RPL33B, RPL34A, RPL35A, RPL37A, RPL37B, RPL43A, RPL4A, RPL6B, RPL9A, RPL16B, NOP16, ARX1, ASC1, DBP3, HCR1, TMA20, TMA22RPS21B, RPS8A, ASC1,a DBP7, MRT4RPL19B,b DBP3,a RPS23A,b NOP12, CGR1b
8Mitochondrial electron transport/genome/ribosomes and integrityMSS18, COX7, COX10, COX17, COX23, CYT1, CYT2, QCR2, CBP4, COQ10, PET122, PET127, ILM1, PIF1, MGR2, HMI1, RIM1, TOM7, TOM70, YMC2, YDL119C, SWS2, [HAP2, HAP3, HAP5; CCAAT-binding complex]UTH1aSWS2,a MRP49, TIM18,b YME1, YME2b
9Tyrosine phosphataseOCA1, OCA2, OCA4, OCA6, SIW14
10Signal transductionBMH1, BMH2
11Bud site selectionBEM3, BUD14, BUD27
12Actin cytoskeleton/cell polarity/mRNA localizationEDE1, RHO4, BNR1, SLA1EDE1*, ARC18, RVS161
13Ergosterol biosynthesisERG5, ERG6ERG2
14Iron ion transportFTR1, FET3
15Aldehyde dehydrogenasesALD5, ALD6
16HO functionASH1, PUF6, SHE4SHE4a
17mRNA degradationSKI2, SKI3, SKI7, SKI8SKI3a
18Phosphate transportPHO86, PHO87
19Killer toxin relatedFYV10, FYV12, KRE1FYV4b
20Protein O mannosylationPMT1, PMT2
21Telomerase holoenzymeEST1, EST2, EST3
22Spindle checkpointBUB1, BUB3, BIM1
23Mitotic exit networkKEL1BFA1, BUB2, LTE1, SWM1KEL2
24TranspositionRTT103, RTT109RTT106b
25Glycerol osmosensingSHO1, FPS1
26Methionine/threonine biosynthesisHOM2, HOM3, HOM6
  • Genes in boldface lie adjacent to other cdc13-1 interactors of the same category (e.g., synthetic); strong suppressors are underlined. A number for each group of genes is indicated on the left.

  • a Also a suppressor of cdc13-1.

  • b Deletion of gene is synthetically lethal with cdc13-1.