TABLE 4

Genes whose deletion imparts a phenotype in the cdc13-1 UP–DOWN assay

UD sensitiveUD sensitiveUD sensitiveUD resistant
ORFGeneORFGeneORFGeneORFGene
YEL033WMTC7aYJR075WHOC1YML032CRAD52[YMR116CASC1b]
[YNL171CYNL171C]YDR158WHOM2YDR217CRAD9bYOR033CEXO1b
[YLR370CARC18]YER052CHOM3YHL027WRIM101YKL029CMAE1
YLR242CARV1YJR139CHOM6YOR275CRIM20YCR009CRVS161
YJR053WBFA1YJL092WHPR5YPR018WRLF2YLR119WSRN2b
YER016WBIM1[YHR067WHTD2]YJL136CRPS21B
YLR015WBRE2YIL154CIMP2′[YBL072CRPS8A]
[YGR188CBUB1]YDR123CINO2YDR289CRTT103
YMR055CBUB2YMR294WJNM1YLL002WRTT109
[YOR026WBUB3]YOR123CLEO1YFR040WSAP155
YMR038CCCS1YPL055CLGE1YMR127CSAS2
YLR418CCDC73YAL024CLTE1YDR181CSAS4b
YBR274WCHK1bYPR164WMMS1YBR171WSEC66
YMR198WCIK1YJL183WMNN11YBL031WSHE1
YPR119WCLB2YCL061CMRC1[YOR035CSHE4b]
YCR086WCSM1YPL184CMRN1YER118CSHO1
YPR135WCTF4[YKL009WMRT4]YKR101WSIR1
YKR024CDBP7YBR057CMUM2bYPR189WSKI3b
YPL194WDDC1bYNL119WNCS2YMR016CSOK2
YKL213CDOA1bYKL040CNFU1YPR032WSRO7
[YDR440WDOT1][YKR082WNUP133]YOR027WSTI1
YKL204WEAP1YKL120WOAC1YMR039CSUB1
YBL047CEDE1bYCR077CPAT1YAR003WSWD1
YOR144CELG1YGR193CPDX1YBR175WSWD3
YKL048CELM1bYDR276CPMP3[YLR182WSWI6]
YMR202WERG2YPL179WPPQ1YDR260CSWM1
YGL054CERV14YGR135WPRE9YOL018CTLG2
YLR233CEST1YMR201CRAD14YKR042WUTH1b
YLR318WEST2YOR368WRAD17bYOR089CVPS21b
YIL009C-AEST3YER173WRAD24bYMR284WYKU70
YLL043WFPS1YKL113CRAD27YMR106CYKU80
YMR307WGAS1bYER162CRAD4YPR024WYME1c
YDR108WGSG1
  • Underlined genes lie adjacent to other genes whose deletion imparts a phenotype in the UP–DOWN assay distinct from cdc13-1 alone. In such cases, an effect on transcription of the neighboring gene cannot be discounted. Brackets indicate genes previously identified as synthetic with wild type during SGA (Tong et al. 2001).

  • a The MTC gene name is reserved for previously un-named ORFs.

  • b Also a suppressor of cdc13-1 and so “RAD9-like” (see Table 1).

  • c Also classed as synthetic sick.