TABLE 3

Genes whose deletion exacerbates the growth defects of cdc13-1 cells

Synthetic lethalSynthetic sick
ORFGeneORFGeneORFGene
YJL123CMTC1aYKL098WMTC2YMR035WIMP2
YNL196CYNL196CYGL226WMTC3YGR238CKEL2
YOR058CASE1YBR255WMTC4YOL064CMET22
YGL029WCGR1YDR128WMTC5YKL167CMRP49
YBR036CCSG2YHR151CMTC6YOL041CNOP12
YHR059WFYV4YDL218WYDL218WYML103CNUP188
YEL003WGIM4YIL040WAPQ12YBR093CPHO5
YNL014WHEF3YBR131WCCZ1YIL153WRRD1
YOL108CINO4YGR157WCHO2YHR178WSTB5
YNL106CINP52YGL078CDBP3bYBR231CSWC5
YKL176CLST4YCL016CDCC1YNL081CSWS2b
YGR078CPAC10YDL219WDTD1YJL138CTIF2
YNL015WPBI2YLR342WFKS1YPR173CVPS4
YNL003CPET8YDL222CFMP45YPR024WYME1c
YBL027WRPL19BYHR108WGGA2YGL255WZRT1
YGR118WRPS23AYML121WGTR1bYOL012CHTZ1
YNL206CRTT10
YOR297CTIM18
YNL197CWHI3
YMR302CYME2
  • Underlined genes lie adjacent to other genes whose deletion has synthetic interactions with cdc13-1. In such cases, an effect on transcription of the neighboring gene cannot be discounted.

  • a The MTC gene name is reserved for previously unnamed ORFs.

  • b Also a suppressor of cdc13-1 (see Table 1).

  • c Also classed as UDS.