TABLE 3

McDonald–Kreitman tests at MSL-binding sites vs. flanking regions

Pairwise divergenceLineage-specific divergence
Binding siteNonbinding siteBinding siteNonbinding site
PDPDP-valuePD_ANCPD_ANCP-value
D. melanogaster
    18D10103539490.009*10933130.117
    roX121171580.006*2767350.014*
    roX211025560.1221625270.097
    Combined1356135163<0.001*1322125750.005*
D. simulans
    18D10391970450.83832758160.757
    roX131079610.021*3378200.12
    roX2352439330.77911360120.459
    Combined77531881390.6714613196480.403
D. yakuba
    18D101559241140.760153723710.782
    roX1111111320.76617111070.831
    roX2117411370.068113401040.078
    Combined1787763830.5451757742820.722
  • P, number of polymorphic sites; D, number of divergent sites from an outgroup species (D. simulans for the D. melanogaster and D. yakuba populations and D. melanogaster for the D. simulans population); D_ANC is the number of divergent sites from a reconstructed outgroup species. P-values are from Fisher's exact test. *P < 0.05.