TABLE 4

Quantitative trait loci for craniofacial traits in pedigreed baboons

Baboon (PHA)Human region orthologous to 1-LOD support interval
TraitNh2aEmbedded ImageaLODPbChromosomecMcCytogenetic locationWidth (ntb)No. of known genesd
Posterior condylion8250.120.1563.340.01113512p2113,618,455104
NeuroPC38300.360.1193.120.0202693q13.1348,871,949356
S–N–Pr8220.340.1223.170.01821093q11.28,191,8685
Go–Gn–S8150.330.1162.940.03121103q11.215,687,19714
S–PNS8110.370.1022.930.0214276p21.29,392,31530
Facial taper8110.470.1473.320.0124446q1217,144,062341
Ba–Ar8190.00.1133.960.0034536q1518,360,803374
S–X1108300.400.1663.010.02641406q2718,306,10980
S–X1008300.410.1703.010.02641406q2718,306,10980
N–S–Ba8220.240.0963.450.00911012p13.335,296,63642
Ba–PNS8080.280.1313.700.005111412p13.339,205,306114
Facial taper8110.530.0942.890.035175013q31.316,531,78382
N–Pr8220.250.1932.880.036165417p1219,688,343400
  • ntb, nucleotide bases.

  • a Maximum-likelihood heritability estimates from linkage models: Embedded Image is the QTL-specific heritability, i.e., the proportion of the residual phenotypic variance due to the effect of the QTL, and h2 is the residual heritability, i.e., the proportion of the phenotypic variance in the trait due to the effects of genes other than the QTL.

  • b Genomewide P-value associated with the LOD score calculated using a modification of a method suggested by Feingold et al. (1993) that takes into account pedigree complexity and the finite marker density of the baboon whole-linkage map used in these analyses.

  • c Location in centimorgans from the pter-most marker locus in the baboon genetic linkage map for that chromosome.

  • d Within regions of human syntenic groups likely to be orthologous to the region of the baboon genome containing the 1-LOD support interval for the QTL.