TABLE 3

Inbreeding coefficients and gene diversity components for five amino acid polymorphisms in the HBA-T1 and HBA-T2 genes that exhibit significant allele frequency differences between high- and low-altitude samples

Amino acid polymorphismFIS (high)aFIS (low)aFITHSHTDSTPGb
HBA-T1
α50(CD8)His/Pro0.3730.2560.4910.4250.5010.0770.0077
α57(E6)Gly/Ala−0.044−0.2470.0040.3680.4050.0380.0029
α60(E9)Ala/Gly−0.032−0.397−0.1050.2890.3170.0290.0046
α64(E13)Asp/Gly−0.067−0.0440.2180.3360.3940.0580.0022
α71(EF1)Gly/Ser−0.044−0.2110.0570.3760.4220.0460.0023
HBA-T2
α50(CD8)His/Pro−0.1030.2060.3530.3660.4330.0670.0033
α57(E6)Gly/Ala−0.076−0.1660.0190.3870.4180.0310.0262
α60(E9)Ala/Gly−0.067−0.1800.0050.3070.3310.0240.0230
α64(E13)Asp/Gly−0.103−0.1850.0480.3550.3940.0390.0079
α71(EF1)Gly/Ser−0.076−0.1660.0190.3870.4180.0310.0275
  • For both genes, the set of five polymorphisms defines functionally distinct allele classes.

  • a “High” and “low” refer to population samples from Mt. Evans, Colorado, and Yuma County, Colorado, respectively.

  • b Unbiased P-value from an exact test of genotypic differentiation.