TABLE 2

Summary of nucleotide polymorphism and LD at nuclear loci

SampleNaSbπ (silent)θW/bp (silent)Tajima's DRMinρ/bpγ/bpcZnS
α-Like globin genes
HBZ (1884 bp)High altitude18890.01260.0134−0.2565140.06680.03462.3550.1687
Low altitude181200.01610.0185−0.5490230.15930.04102.0930.1201
Total361560.01490.0194−0.8591230.11070.04592.1590.0742
HBA-T1 (1680 bp)High altitude341770.02130.0253−0.5997150.00480.02610.8510.1545
Low altitude342230.02950.0315−0.2337240.01180.04381.1360.1613
Total682460.02620.0295−0.3966270.00900.03991.0980.1160
HBA-T2 (1680 bp)High altitude341700.02060.0244−0.5857250.00260.03961.3290.1696
Low altitude341910.02800.0286−0.0715280.01140.04661.3930.1810
Total682390.02600.0305−0.5155380.00810.04931.3780.1317
HBQ (920 bp)High altitude24350.00580.0094−1.471620.04480.01751.6960.1114
Low altitude28640.00940.0142−1.267360.06370.03531.9200.1367
Total52790.00790.0151−1.6611100.03840.03411.7490.0776
HBA-T3 (743 bp)High altitude26690.01290.0140−0.2817100.01710.05201.8890.1868
Low altitude25890.01310.0210−1.4463110.05210.08112.2610.1117
Total511010.01330.0193−1.0818160.03980.07042.0600.0869
Unlinked nuclear loci
β-fibrinogen (619 bp)High altitude29290.00660.0126−1.72320.10560.01311.0430.0759
Low altitude29230.00570.0100−1.53410.01820.01631.6300.1517
Total58400.00620.0147−1.93350.05190.02351.5970.0428
LCAT (456 bp)High altitude27180.01080.00940.521660.16680.02992.8250.1300
Low altitude27180.01080.0108−0.028260.67120.05645.2010.0855
Total54220.01130.01010.381690.75000.04884.4080.0601
RAG1 (1183 bp)High altitude28260.00360.0044−0.639460.15830.01332.3140.0841
Low altitude22190.00290.0031−0.171130.00680.00030.0730.2589
Total50350.00350.0046−0.746480.07540.00801.1880.0816
AP5 (385 bp)High altitude27250.01730.01410.802350.25620.16339.2590.0950
Low altitude27260.01810.01610.455490.68680.15798.6920.0785
Total54360.01840.01720.2194120.63160.16317.6310.0483
Vimentin (785 bp)High altitude30600.01290.0208−1.43170.02530.02511.2050.1197
Low altitude28970.02410.0343−1.15270.09080.03070.8950.1085
Total581290.01920.0383−1.75290.03670.03240.8450.0595
Rhodopsin (1319 bp)High altitude241130.01880.0251−1.000210.33480.05932.3600.0867
Low altitude201230.02010.0281−1.170180.98630.05181.8450.1050
Total441760.02020.0332−1.436292.5080.07012.1000.0456
  • Estimates of π, θW, Tajima's D, and ZnS are based on variation at silent sites. “High altitude” and “low altitude” samples refer to Mt. Evans, Colorado, and Yuma County, Colorado, respectively.

  • a Number of sampled chromosomes.

  • b Number of segregating sites.