TABLE 2

Haplotype-based association analysis in Western breeds

Haplotype frequencyb
HaplotypeaNormalPPDOdds ratio (C.I. of 95%)cχ2 (1)P-valuedPc valuee
1-CCCAGC0.2500.7278.00 (2.76 23.22)20.954.60 × 10−62.30 × 10−5
2-CCCAAC0.1250.0005.880.0150.075
3-TCCCAC0.3120.0686.21 (1.54 25.11)8.710.00320.016
4-TCCCGC0.2500.1372.11 (0.74 6.33)1.880.17
5-CTTAGT0.0630.0681.09 (0.21 5.80)0.010.91
  • a The SNPs used to construct haplotypes are Int16, Int15, Int6, ZRSi5, ShotR2, and Int3, whose positions on the canine genome are designated in supplemental Table 6S.

  • b Individuals were selected from nine breeds, including 24 normal (10 homozygous and 14 heterozygous) and 22 PPD dogs (10 homozygous and 12 heterozygous).

  • c C.I. denotes the confidence interval.

  • d The P-values for the genotype level association with haplotype 1 are 6.27 × 10−62 = 20.40) and 1.31 × 10−22 = 6.15) for dominant and recessive modes of inheritance, respectively.

  • e The P-values were corrected by multiplying the number of haplotypes.