Haplotype frequency^{b} | ||||||
---|---|---|---|---|---|---|

Haplotype^{a} | Normal | PPD | Odds ratio (C.I. of 95%)^{c} | χ^{2} (1) | P-value^{d} | P_{c} value^{e} |

1-CCCAGC | 0.250 | 0.727 | 8.00 (2.76 23.22) | 20.95 | 4.60 × 10^{−6} | 2.30 × 10^{−5} |

2-CCCAAC | 0.125 | 0.000 | 5.88 | 0.015 | 0.075 | |

3-TCCCAC | 0.312 | 0.068 | 6.21 (1.54 25.11) | 8.71 | 0.0032 | 0.016 |

4-TCCCGC | 0.250 | 0.137 | 2.11 (0.74 6.33) | 1.88 | 0.17 | |

5-CTTAGT | 0.063 | 0.068 | 1.09 (0.21 5.80) | 0.01 | 0.91 |

↵

*a*The SNPs used to construct haplotypes are Int16, Int15, Int6, ZRSi5, ShotR2, and Int3, whose positions on the canine genome are designated in supplemental Table 6S.↵

*b*Individuals were selected from nine breeds, including 24 normal (10 homozygous and 14 heterozygous) and 22 PPD dogs (10 homozygous and 12 heterozygous).↵

*c*C.I. denotes the confidence interval.↵

*d*The*P*-values for the genotype level association with haplotype 1 are 6.27 × 10^{−6}(χ^{2}= 20.40) and 1.31 × 10^{−2}(χ^{2}= 6.15) for dominant and recessive modes of inheritance, respectively.↵

*e*The*P*-values were corrected by multiplying the number of haplotypes.