TABLE 5

Model for relative differences in protein solubility, processes influencing prion phenotype, and Ssa protein responsible for prion-specific effects

ProteinPropagationSsapa
Prion phenotypeSolubleInsolubleGrowthReplication[PSI+][URE3]
Strong, stableLowHighFastFastSsa1p, 3pSsa2p
Strong, unstableLowHighFastSlowNOSsa1p
Weak, stableHighLowSlowFastSsa2p, 4pSsa4p
Weak, unstableHighLowSlowSlowNOSsa3p
  • NO, not observed.

  • a The indicated wild-type Hsp70 is the only Ssap in the cell.