TABLE 2

The mlh3Δ and mlh3-D523N mutations confer similar mutator phenotypes

GenotypenMutation rate (10−7), (95% C. I.)Relative to wild type
Wild type179.0 (6.8–17)1
MLH3-KANMX168.3 (6.0–18)0.92
mlh3Δ1757 (41–114)6.3
mlh3-D523N1871 (42–130)7.9
  • The indicated derivatives of EAY1062 (SK1 wild type) were tested in the lys2∷insE-A14 mutator assay for reversion to Lys+. n, number of independent cultures tested.