TABLE 3

Estimated within-line correlation (ρ) and variance components (variance of main QTL effect Embedded Image, epistatic variance Embedded Image) for four simulated scenarios

Simulated valuesEmbedded ImageEmbedded ImageEmbedded Image
ρEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
Case 11.0010.00.9810.630.40*1.0010.865.451.0013.739.71
Case 20.688.800.668.740.38*0.808.385.800.888.9410.63
Case 30.206.250.216.290.63*0.345.785.870.465.1511.35
Case 40.004.440.004.620.44*0.023.705.830.024.0210.28
  • The simulated cases 1–4 cover scenarios from total fixation to complete segregation within lines. One hundred replicates of an F2 pedigree with four founders and 800 F2 individuals with a QTL effect having a 5% heritability in an outbred base population were simulated. Bias with P < 0.05 is in italics, P < 0.01 is underlined, and * indicates biased estimates (P < 0.01) but with median value <0.02.