TABLE 3

Stability conditions

No dominanceH partially dominanth partially dominant
(hH = hh = 0)(hh = 0; 0 < hH < 1)(hH = 0; 0 < hh < 1)
A. One-locus model
Embedded Image stable (hotspot maintained)Embedded ImageEmbedded ImageEmbedded Image
Embedded Image unstable (hotspot increases in frequency)Embedded ImageEmbedded ImageEmbedded Image
Embedded Image unstable (assuming βH and βH − βh are small)Embedded ImageEmbedded ImageEmbedded Image
B. Modifier model
pM = 0 unstable (hotspot-activating modifier increases in frequency)Embedded ImageEmbedded ImageEmbedded Image