TABLE 3

Effect of Aβ modifiers on tau and httex1Q93

Mutationtau eyeQ93 eyeAβ eyeAβ lifeGene/function
Dsp1EP(X)0355LaEb (102)EEDsp1
svrEP(X)0356Sc (186)S (72)EEsilver
gEP(X)0514S (12)S (70)SNEdgarnet
EP(X)1318E (12)NE (49)SLUnknown
EP(X)1504S (19)NE (37)EEUnknown
EP(X)1596S (41)S (99)SENICE5(Ubc) or CG2918 (stress response) or CG3071 (vesicular transport)
CG2924EY02142NTNE (62)NE (227)NT
EP(X)0308S (38)S (189)SEATP7 or HSP20
ATP7EY07895NTS (40)E (220)NTATP7
EP(2)0684esgLLELescargot
EP(2)0330S (60)S (90)EEUnknown
MESR4EP(2)0386S (50)S (53)ENEMESR4
elBEP(2)0965NTNTEEelbB
CG7231EP(2)2510NTNTELUnknown
EP(3)0595bS (44)E (25)EEFGF signal or CG6745 (unknown)
EP(3)1051LE (53)EEToll
SnfγEP(3)3015bLE (22)ENESnfγ
EP(3)3041LNE (98)EEUnknown
EP(3)3099LS (94)EERhoBTB or IDE
mubEP(3)3108S (116)S (83)EEmub
EP(3)3348S (125)S (116)SESAP130 or ATG1
SAP13006924NTNE (88)NENTSAP130
EP(3)3405S (14)NE (50)SEUnknown
EP(3)3470LNE (54)EECG17100 or Rfx
nep2EP(3)3549LNE (64)SSnep2
EP(3)3603S (17)S (23)SEGlial cell differentiation or UbcD4
UbcD4EY05497NTS (118)NE (129)NTUbcD4
  • The number of flies screened is shown in parentheses.

  • a Lethal.

  • b Enhancer.

  • c Suppressor.

  • d No effect.