TABLE 1

Modifiers of Aβ phenotypes

MutationDirection of UASaPredicted type of mutationCandidate gene rtPCRGene name/functionBiological processHuman orthologAβ eyeb
Dsp1EP(X)0355SameGofc/Gal dependentNTdDsp1 corepressorChromatin assemblyHMG-B1Ee (89)
svrEP(X)0356SameLoff/3′ exonNTSilver (CypD)Secretory pathwayCarboxypeptidase DE (59)
svrKG02090LofNTE (61)
svr126LofNTE (58)
gEP(X)0514OppositeLof/Gal independentNTgarnetLysosomal transportAP-3 subunit delta-1Sg (132)
gB166LofNTS (14)
EP(X)1318Not mappedS (33)
EP(X)1504Gal independentNTNot mappedE (96)
EP(X)1596 (CG2924)OppositeLof/Gal independentNTUbiquitin-conjugating enzymeUbiquitin/proteolysisUbiquitin-conjugating enzyme E2QS (35)
CG2924EY02142SameUnclearNTNEh (227)
EP(X)0308Gal dependentATP7 or HSP20Cu transport or protein foldingATP7 or CML antigen 66S (71)
ATP7EY07895SameGof2.8-foldATP7Cu transportCopper-transporting ATPase 1/2E (220)
EP(2)0684esgSameGof/Gal dependentNTEscargot/transcriptional repressorCNS developmentSnail homolog 2E (62)
EP(2)0330No flanking sequenceGal independentNot mappedE (68)
MESR4EP(2)0386SameGof/Gal dependentNTMESR4 misexpression suppressor of RasChromatin regulationPELP1 human isoform 2E (143)
elBEP(2)0965SameInconclusiveMultiple transcriptsElbow (elbB)Zn-finger/cell cycle—eyeZn-finger protein 503E (21)
elB9LofNTE (177)
EP(2)2510 (CG7231)OppositeLofNTCG7231Not knownNM205548 novel proteinE
EP(3)0595bSameTwo genesCG6745 or CG6765FGF signalingPseudouridil. synthase7/no ortholog for CG6765E (224)
EP(3)1051SameGof/Gal dependent4.6-foldTollImmune responseToll-like receptor 4E
SnfγEP(3)3015bSame/3′ endLof?Multiple transcriptsLochrig/AMPγEnergy metabolism/ cholesterol homeostasisAMP kinase γ-subunitE (59)
SnfγKG10152LofNTE (111)
EP(3)3041SameGof/Gal dependentNTUnknown/mir282E (137)
EP(3)3099Gal dependentNTRhoBTB (lof) or IDE (gof)Signal transduction or insulin degrading enzymeSmall GTPase or IDEE (144)
mubEP(3)3108OppositeLof/Gal independentNTMub/mushroom bodyRegulation of translationPoly(rC)-binding protein 3E (159)
mub04093Lof?(intron)NTNE (34)
EP(3)3348Two genesSAP130 or ATG1Transcription regulation or autophagymSIN3A-associated protein or ATG1S (234)
SAP130EY12079Same/codingLof0.5-foldSAP130Chromatin transciption regulationmSIN3A-associated proteinE (142)
Rpd304556LofNTRpd3Chromatin transciption regulationHDAC1E (56)
HDAC4KG09091LofNTHDAC4Chromatin transciption regulationHDAC4E (23)
Sin3A08269LofNTSin3AChromatin transcription regulationTranscription corepressor Sin3bE (76)
EP(3)3405SameGof/Gal dependentNTCG6175Unknown functionNo orthologS (27)
EP(3)3470Same (3.6 kb)Gof/Gal dependentNTStichTranscription regulationhairy/enhancer of split relatedE (59)
nep2EP(3)3549SameGof/Gal dependent6.5-foldnep2ProteolysisNeutral endopeptidaseS (130)
nep2KG05754LofNTE (22)
EP(3)3603OppositeLof/Gal independentNTCG6767 or UbcD4S (233)
CG6767KG00420LofNTCG6767Glial cell differentiationRibosyl-pyrophosphosynthetaseE (24)
UbcD4EY05497OppositeLofNTUbcD4UbiquitinationNE (129)
  • The 23 EP insertions identified in the original genetic screen are underlined.

  • a Direction of UAS element relative to transcription of candidate gene.

  • b The number of experimental flies screened is in parentheses.

  • c Gain-of-function mutation.

  • d Not tested.

  • e Enhancer.

  • f Loss-of-function mutation.

  • g Suppressor.

  • h No effect.