TABLE 3

Synthetic genetic interactors with gem1Δ

Strong synthetic interactionsMedium synthetic interactionsWeak synthetic interactions
FMP13aAPP1bAAH1
MMR1aATP1AEP1
PHB2bCHO2ARO8
TOM70aCOQ5ATP10
YGR182CcCYT2ATP12
ICE2aATP7
OPI3BRE5
PLP1CCE1
PTC1COX19
SNF1EOS1
YER093C-AFMP24
YHM2FMP30
YLR253WGCN1
IMP1
MDM38
MRPL3
MSS18
MSS51
NPT1
PET122
RMD11
TIM13
VTS1
YDL162C
YGL057C
YGL226W
YLR422W
YPL183W-A
  • Most genes identified as synthetic genetic interactors with gem1Δ encode mitochondrial proteins. Interaction between gem1Δ and deletions of the listed genes were all confirmed by random spore analysis. Underlined gene names encode proteins with a mitochondrial localization annotated in the Saccharomyces Genome Database (SGD, http://www.yeastgenome.org). Gene names in boldface type have annotated affects on mitochondrial or ER morphology or inheritance. Strength of genetic interaction was based on relative double-mutant fitness and reproducibility.

  • a Interactions confirmed in the W303 strain background.

  • b Interactions confirmed by dissection in the strain background used for the screen.

  • c YGR182c is a dubious ORF and the deletion is a truncation allele of TIM13.