TABLE 5

Genes showing differential expression between daf-2 and daf-16; daf-2 in e1370 but not in m577

daf-2 vs daf-16; daf-2 mean log2 fold-changeqGene sequence nameProtein
Upregulated in daf-2
6.130.000961Y39H10A.1Similarity to Bradyrhizobium sp. Hypothetical protein TR:Q35RI1
5.3180.00204F08H9.4IPR002068 heat-shock protein Hsp20
3.7070.0101F08H9.3IPR002068 heat-shock protein Hsp20
3.7540.00795gst-41IPR004045 glutathione S-transferase, N-terminal
3.5720.0276T20D4.12IPR002542 protein of unknown function DUF19
3.480.0209F20A1.6Similarity to Dictyostelium discoideum TR:Q55ED2
3.4170.00252cyp-13B1IPR001128 cytochrome P450
3.220.0233C45G7.3Similarity to Interpro domain IPR008597 (Destabilase)
3.070.0732F46F5.15Similarity to Saccharomyces cerevisiae GAP; negatively regulates RAS
3.030.0414tyr-3Predicted tyrosinase
2.9820.00838T20G5.8IPR003582 metridin-like ShK toxin
2.9080.0514C34B2.4IPR001781 LIM, zinc binding
2.8520.0126ins-22IPR004825 insulin/IGF/relaxin
2.8230.0749F35E8.6IPR003582 metridin-like ShK toxin
2.810.0734F09E10.10Probable noncoding RNA
2.770.0621W08A12.4Similarity to Oryctolagus cuniculus trichohyalin; SW:P37709
2.730.0317F36D1.7Similarity to Clostridium cellulovorans hydrophobic protein A
2.710.0480C08A9.3Similarity to Mus musculus SID1; SW:Q8CIF6
2.6450.0611F49E11.6IPR001283 allergen V5/Tpx-1 related
2.6150.0321M162.5IPR007114 major facilitator superfamily
2.540.0180T23F2.4Similarity to Pfam domain PF01679
2.380.0248F19F10.3Similarity to Burkholderia thailandensis TR:Q2SYY4
2.2840.0352Y38E10A.11IPR009853 protein of unknown function DUF1412
2.180.0249C50D2.6Similarity to D. melanogaster CG9896-PA
1.970.0850B0563.5Similarity to Desulfovibrio desulfuricans metal-dependent phosphohydrolase
1.930.0433Y43C5A.3Similarity to Ixodes scapularis putative secreted salivary gland peptide
1.760.0669F20A1.10Similarity to H. hepaticus Seryl-tRNA synthetase
1.7030.0731nhr-206IPR000324 vitamin D receptor
Downregulated in daf-2
−7.0840.000238F22A3.6IPR008597 destabilase
−3.5420.0323C52E2.5IPR001810 cyclin-like F-box
−3.5270.00422T16G12.1IPR001930 peptidase M1, membrane alanine aminopeptidase
−3.4940.0216R03G8.6IPR001930 peptidase M1, membrane alanine aminopeptidase
−3.1280.00234C17H12.8IPR003366 protein of unknown function DUF141
−2.8260.0272F52F10.4IPR002656 acyltransferase 3
−2.7550.00648R09H10.5IPR006582 MD
−2.6530.00878T01D3.6IPR001846 von Willebrand factor, type D
−2.5530.0176amt-4IPR010256 Rh-like protein/ammonium transporter
−2.4960.0277F28B4.3IPR006209 EGF-like
−2.3490.0173C41A3.1IPR008262 lipase, active site
−2.3070.0188K11H12.4IPR005071 protein of unknown function DUF274
−2.2970.025T25B6.2IPR002052 N-6 adenine-specific DNA methylase
−2.180.0252K09C4.1IPR007114 major facilitator superfamily
−2.0550.0831R193.2IPR002035 von Willebrand factor, type A
−2.0420.0354glc-1IPR006201 neurotransmitter-gated ion channel
−1.9850.0415C12D8.5IPR005806 Rieske [2Fe-2S] region
−1.9320.0323fat-7IPR005804 fatty acid desaturase
−1.9100.0372C29F7.2IPR004119 protein of unknown function DUF227
−1.8890.0693ugt-43IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
−1.8700.0541K08D8.6IPR003366 protein of unknown function DUF141
−1.830.0611C11E4.7Similarity to Trichodesmium erythraeum aminotransferase, class I and II
−1.8090.0547ckb-2IPR002573 choline/ethanolamine kinase
−1.740.00950F08G5.6IPR003366 protein of unknown function DUF141
−1.660.0695C18H9.6Similarity to Geobacter metallireducens replication initiation factor
−1.540.0482F15E11.12Similarity to Wolinella succinogenes hypothetical protein, TR:Q7MR69
−1.3930.0947ugt-22IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
−1.1170.0182asp-1IPR001461 peptidase A1, pepsin