TABLE 1

Estimates of summary statistics for the RRM2P4 central and flanking regions

RegionDemenLengthSθw/bp (%)Lower 5% quantileθπ/bp (%)95% confidence interval
5′Global83172750.0580.068(0.052, 0.081)
African37172750.0690.084(0.059, 0.098)
Non-African46172730.0400.056(0.034, 0.073)
CentralGlobal2532320220.1550.1200.110(0.093, 0.126)
African1312320160.1260.0710.077(0.066, 0.087)
Non-African1222320150.1200.1040.136(0.105, 0.163)
3′Global83161270.0880.061(0.037, 0.081)
African37161240.0600.081(0.044, 0.108)
Non-African46161260.0850.041(0.014, 0.067)
  • Statistical confidence was determined from 104 bootstrap replicates. SNP diversity, θW, is significantly lower in the flanking regions than in the central region (α < 0.05). African θπ-values do not differ significantly among regions (α > 0.05), but non-African θπ- and θW-values are significantly higher in the central region. Within sequenced regions, non-Africans have significantly higher θπ relative to Africans in the central region only (P ≪ 0.001, underlined). This effect is not observed in the 5′ (P = 0.966) or 3′ regions (P = 0.957).