TABLE 2

Phenotypic mutation rates

Mutation rate (mutations/genome/generation)
Cloneα-FactorR (×10−6)CanR (×10−7)5-FOAR (×10−8)
A5.51 (4.31–6.82)2.08 (1.67–2.51)6.49 (4.89–8.24)
B5.51 (4.31–6.81)1.81 (1.44–2.20)4.77 (3.53–6.15)
C6.28 (4.96–7.70)2.21 (1.77–2.69)7.19 (5.49–9.07)
D6.58 (5.23–8.04)1.88 (1.51–2.29)5.08 (3.73–6.58)
E5.60 (4.40–6.90)2.06 (1.66–2.50)4.48 (3.25–5.85)
F6.07 (4.81–7.44)1.87 (1.49–2.28)6.70 (5.10–8.45)
G5.35 (4.21–6.59)1.76 (1.41–2.14)4.74 (3.50–6.12)
H6.05 (4.79–7.42)2.05 (1.65–2.49)5.01 (3.69–6.47)
I6.00 (4.76–7.36)1.79 (1.43–2.17)7.03 (5.33–8.90)
J5.50 (4.35–6.76)2.09 (1.67–2.55)3.05 (2.11–4.11)
Average ± SD5.85 ± 0.411.96 ± 0.165.45 ± 1.34
Combined5.86 (5.46–6.28)1.95 (1.83–2.08)5.43 (4.97–5.91)
  • Mutation rates to α-factor resistance, canavanine resistance (CanR), and 5-fluoroorotic acid resistance (5-FOAR) for 10 clones of GIL104. Parentheses indicate the 95% confidence intervals calculated using Equations 29 and 30 from Foster (2006). The combined data set treats the 10 72-tube fluctuation assays as one 720-tube fluctuation assay.