TABLE 5

Estimates of mean selective effect and distribution shape parameter for deleterious mutations in humans and Drosophila

SpeciesPopulationData setNeE(s) (95% C.I.)β (95% C.I.)
H. sapiensAfricaPGA5,300 (160, →∞)0.10 (0.01, 0.19)
Europe51 (16, →∞)0.19 (0.04, 0.32)
AfricaEGP2,500 (180, →∞)0.15 (0.02, 0.25)
Europe61 (16, 4.8 × 105)0.29 (0.08, 0.54)
D. melanogasterAfricaShapiro et al. (2007)1,800 (520, 25,000)0.38 (0.26, 0.49)
Zimbabwe9,800 (700, →∞)0.30 (0.15, 0.49)
Non-Africa14,000 (290, →∞)0.27 (0.04, 0.59)