TABLE 2

Polymorphism and divergence along the D. melanogaster and D. simulans branches by previously described domains for the four DCC genes exhibiting adaptive protein evolution

D. melanogaster branchD. simulans branch
GeneDomainCodon positionπ (N)π (S)dNdSdN/dSdNdSdN/dS
mleRNA binding2–700.00000.00000.0190.0400.480.0000.0830.00
Helicase/ATP binding394–5600.00000.00200.0110.0140.790.0080.0690.12
C-terminal helicase639–8130.00000.00000.0050.2900.190.0030.0220.12
Extradomain0.00020.00060.0010.0460.210.0160.0590.28
mofChromodomain395–4500.00000.01000.0000.1800.000.0100.0190.51
HAT-Zn575–7600.00000.00000.0020.0900.030.0020.1100.02
Extradomain0.00400.00600.0270.0720.260.0120.0570.21
msl1X-binding1–26NANA0.0800.0651.30.0000.0000.00
Glycine rich26–740.00000.00000.0700.0501.50.0190.0120.26
LZ/apolar/coiled coil113–1590.00000.01800.0700.1000.670.0000.1900.00
MOF interaction site766–9390.00000.00300.0180.0190.010.0000.0000.00
MSL3 interaction site973–10390.00000.00600.0150.0170.080.0000.0000.00
Extradomain0.00200.00600.0280.0710.390.0210.0530.16
msl2Cysteine rich521–5610.00000.02100.0000.0000.000.0000.0650.00
Extradomain0.00400.02200.0350.1200.290.0110.0600.17
msl3CBD35–720.00000.00700.0000.1500.000.0000.0310.00
Polar region72–1510.00200.01400.0120.0062.000.0050.1000.05
MRG200–4800.00200.03000.0090.0730.120.0040.000NA
Extradomain0.00200.04000.0400.1200.340.0030.1100.03
  • d, divergence; N, nonsynonymous; S, synonymous; extradomain, region outside currently annotated domains.