TABLE A1

Type and diplotype combinations for two individuals

Type of combination1234567
Diplotype of individual 1hahahahahahbhahbhahahahahahb
Diplotype of individual 2hahahahbhahbhahchbhbhbhchchd
  • This system of types of diplotype combinations can also be used when analyzing families with only full sibs. In our method, a collapse technique is used to calculate the probabilities of parental combinations. For two full sibs, as shown in Table A2, their possible diplotype combinations can be listed first, and for each possible combination, several possible parental combinations can be inferred, and the probability of each parental combination can be calculated given the population haplotype frequencies. For multiple sibs, those diplotype combinations that are not compatible with the extra offspring are excluded.