TABLE 3

Average rate of fitness loss with a delta-function distribution of s-values

NUsR1DaNebbU2cs2cEmbedded Imaged
1040.10.00060.06066670.100.0060.067
1040.10.0010.05840000.0990.0010.062
1040.10.0030.03913330.0940.0030.048
1040.10.010.0154000.0680.010.022
1040.10.020.00312000.0220.020.0023
  • a Ratchet rate in the 1D Haigh model for the given values of N, U, and s.

  • b Effective population size calculated as Neb = 4/s.

  • c Effective mutation rate and selection coefficient for the fraction of sites that are classified as category 2 as described in the text; the fraction of sites located in category 2 is U2/U.

  • d Click rate in the category 2 sites calculated from a 1D Haigh model with parameters Neb, U2, and s2. When s approaches 0.0243, R1D of the Haigh model is 0.01U and all sites would be located in category 1 giving U2 = Embedded Image