TABLE 5

Rescuing haplo-insufficiency

DuplicationDeficiencyDeletion cytologyDeletion sizeDeletion phenotype
Dp(2;2)EDP5Df(2L)ED16522F4–23B81379,732Lethal over SM6a
Dp(2;2)EDP5Df(2L)ED18323A3–23C21156,582Lethal over SM6a
Dp(2;2)EDP5Df(2L)ED18423A3–23C21154,547Lethal over SM6a
Dp(2;2)EDP5Df(2L)ED19523A3–23C41265,279Lethal over SM6
Dp(2;2)EDP5Df(2L)ED19623A3–23C41263,244Lethal over SM6a
Dp(2;2)EDP5Df(2L)ED16722F4–23B81380,892Lethal over SM6a
Dp(2;2)EDP3Df(2L)ED20923A3–23C51302,629Lethal over SM6a
Dp(2;2)EDP6Df(2L)ED38925F5–26D7663,854Weak over SM6a
Dp(2;2)EDP1Df(2L)ED37826B2–26D7465,644Weak over SM6a
Dp(2;2)EDP1Df(2L)ED646126C1–26F3379,912Haplo-semilethal
Dp(2;2)EDP26Df(2L)ED52228D3–28E1294,779Minute
Dp(2;2)EDP9Df(2L)ED67829F5–30B12623,585Weak over SM6a
Dp(2;2)EDP9Df(2L)ED71630E1–31B13333,105Haplo-lethal
  • Chromosome 2L duplications that can rescue otherwise inviable DrosDel deletions. Duplication descriptions are from Table 4. The relevant DrosDel deletion along with its size and predicted cytology are given. The phenotype of the heterozygous deletion is described in the phenotype column. Three of these regions are known to harbor Minute loci: 23B1, 28D2, and 31A3 (S. Marygold and K. Cook, personal communication).