TABLE 1

Estimates of chromosome genetic length L and interference parameter m from female mouse CO mapping along genetic maps (data from Broman et al. 2002) or from male mouse MLH1 foci mapping along bivalents (data from Froenicke et al. 2002)

ChromosomeLMLH1 (cM)mMLH1 FICmMLH1 χ2LCO (cM)mCO FIC
176.2252098.49
277.79887.29
363.1263075.522
470.1141289.46
572.0504582.410
659.7151767.012
768.191071.89
860.8151867.69
955.7243467.69
1061.781062.228
1169.9141268.111
1254.64856.44
1351.45966.023
1453.2505061.711
1549.650a2254.362
1650.050a961.235
1750.950a1649.5b35
1850.950a1041.5b15
1950.050a50a51.6NA
XNANANA76.69
  • For MLH1 foci data, estimates of m are obtained with either the FIC model or the standard chi-square model. For CO data, m was estimated with the FIC model.

  • a For short chromosomes, given the very small number of bivalents with two MLH1 foci, an arbitrary value of m = 50 was used.

  • b For chromosomes 17 and 18, genetic length was estimated from the data of Broman et al. (2002) to values <50 cM. Since such values are not in accordance with the OC constraint and thus are not allowed for the FIC model, we set these chromosome lengths to 50 cM for the simulations.