TABLE 2

Interactions of smc6 and brc1 with excision repair genes

PathwayGeneS. cerevisiae homologsmc6-74abrc1ΔaBrc1 supp of smc6-74
BERmag1MAG1Not epistaticbPartial rescuecYesb
nth1NTH1Not epistaticbNot epistaticcYesb
apn2APN2SLbNot epistaticcNA
rad2RAD27EpistaticdNot epistaticcNA
MMRmsh2MSH2NAeNAeYese
pms1PMS1NAeNAeYese
exo1EXO1Not epistaticfNot epistaticeNof
NERrhp41RAD4SGDgNDNA
rhp14RAD14SGDgNot epistaticeNA
swi10RAD10SGDgNot epistaticeNA
rad13RAD2Not epistaticdNot epistatichYesh
  • SL, synthetic lethal; SGD, synthetic growth defect; ND, not determined; NA, not applicable.

  • a Phenotype in combination with smc6-74 (for MMS and UV-C) or brc1Δ (for MMS).

  • b See Figure 3.

  • c See Figure 4.

  • d From Lehmann et al. (1995).

  • e Supplemental figures (http://www.genetics.org/supplemental/).

  • f See Figure 5.

  • g See Figure 6.

  • h From Sheedy et al. (2005).