APPENDIX A

Transition probabilities when the selected mutation separates the neutral loci

Configuration at end of selection phaseProbability given starting configurationConfiguration at start of neutral phase
00O
0O
0O
0B
O
O
B
C
C
C
00O
0O
0O
00O
• An example of the transition probabilities for the changes in configuration that occur during the selection is given in Figure 2. Here we give the transition probabilities for the different starting configurations. For notation, let represent the configuration where at locus x (to the left of the selected site) the two chromosomes i and j have been sampled and both carry the selected allele and at locus y the same two chromosomes have been sampled and again, both carry the selected allele. Using this notation, is, for example, the configuration where at locus x chromosome i carries the selected allele and chromosome j carries the wild type, while at locus y chromosome i has again been sampled (and therefore by necessity carries the selected allele), while a third chromosome, k, carries the wild-type allele. The transition probabilities during the selection phase for each of the three starting configurations are given below. Note that and that the labels i, j, k, and l are arbitrary identifiers for chromosomes drawn at random (with replacement) from the sample. For example, the configurations and would be equivalent.