TABLE 6

Genetic interaction of sli-3 with other negative regulators

Negative regulatorsli-3% MuvVPC inductionn
++03.0 ± 0.0>100
+sy34103.0 ± 0.050
sli-1(sy143)+03.0 ± 0.030
sy143sy341543.4 ± 0.422
ark-1(sy247)+63.0 ± 0.131
sy247sy341293.2 ± 0.451
unc-101(sy108)+33.0 ± 0.130
sy108sy341523.4 ± 0.421
gap-1(n1691)+03.0 ± 0.025
n1691sy341804.0 ± 0.715
  • The Muv phenotype and VPC induction were examined in L4 stage animals under a Nomarski microscope. Data for the ark-1(sy247); sli-3(sy341) double were pooled from two different genotypes, dpy-10(e128) sli-3(sy341); ark-1(sy247) unc-31(e169) (average induction = 3.2, Muv = 25%; n = 24) and unc-4(e120) sli-3(sy341); dpy-20(e1282) ark-1(sy247) (average induction = 3.2, Muv = 33%; n = 27). VPC induction and n are defined in Table 1.