TABLE 1

Multilocus models of HDL QTL

Multiple-QTL analysisDetails of main-effect QTL
IntercrossEffect/QTLd.f.aType III SSa% varaP(f)bQTL nameChrPeak (cM)cC.I. (cM)cLODcPosition of marker (Mb)cdHigh alleleMode of inheritance
Sex120.0548.10
B × AChr 1 at 2 cM60.701.70.00034Hdlq40121.54HeterozygousInteractive
Chr 1 at 48 cM60.741.80.00019Hdlq411485.096A/JInteractive
Chr 1 at 76 cM60.531.30.0041Hdlq4217654–926.4152A/JDominant
Chr 4 at 52 cM20.661.68.95 × 10−6Hdlq4345234–664.4104B6Recessive
Chr 8 at 30 cM62.115.11.60 × 10−13Hdlq4483020–409.460B6Dominant
Chr 15 at 22 cM20.330.80.0026Hdlq4515222–302.644B6Additive
Chr 17 at 26 cM20.300.70.0043Hdlq46172612–423.452B6Recessive
Chr 18 at 26 cM20.350.80.0018Hdlq47182616–343.052B6Recessive
Chr 19 at 4 cM20.280.70.0063Hdlq481940–142.18B6Overdominant
Chr 1 at 2 cM × Chr 1 at 48 cM40.521.20.00096
Chr 1 at 76 cM × Chr 8 at 30 cM40.441.00.0035
Error58316.06
B × CSS-3Sex13.6168.17
Chr 3 at 16 cM20.224.156.9 × 10−5Hdlq4931610–284.232B6Additive
Error1265.29
B × CSS-8Sex13.0952.14
Chr 8 at 50 cM20.8614.51.78 × 10−11Hdlq5085044–5410.8100B6Dominant
Error1442.17
B × CSS-11Sex12.8564.85
Chr 11 at 22 cM20.102.340.0056Hdlq5111226–322.344B6Dominant
Error1501.45
  • —, confidence intervals cannot be accurately estimated due to multiple linked QTL.

  • a Includes contributions of the interactions of main effects.

  • b Based on regression F-test for this term.

  • c Obtained from the single-QTL genome scans.

  • d Megabase positions based on mapped position of peak marker to NCBI build 33.