Recent reports of gene-by-environment interactions in mouse

CovariatePhenotypeQTL (i.e., single locus) or polygenic (e.g., strain) effectMain-effect variancea (%)Interaction-effect variancea (%)Reference
LaboratoryElevated plus mazePolygenic32.7b21bCrabbe et al. (1999)
Body weightPolygenic20.4b7.1b
Cocaine-induced activityPolygenic5.3b8.6b
SexBody weightPolygenic63.7b7b
Open field testPolygenic4.5b
DietObesityQTLYork et al. (1999)
Diet (food shortage)Amphetamine-induced activityCabib et al. (2000)
Maternal lactational environmentPlasma glucosePolygenicReifsnyder et al. (2000)
ExperimenterTail-withdrawal latencyPolygenic4218Chesler et al. (2002)
Testing order
Time of day
LaboratoryLocomotionPolygenic11.9–28.4b10.9–16.5bWahlsten et al. (2003)
Elevated plus mazePolygenic25.2–30b13–14.3b
DietAgressivenessPolygenicNyberg et al. (2004)
DietLiver weightQTLEhrich et al. (2005)
Serum insulinQTL
Fat padQTL
DietLiver weightPolygenicBiddinger et al. (2005)
Glucose tolerance testPolygenic
LaboratoryOpen field testPolygenic0–20.30.1–8.7Kafkafi et al. (2005)
SexGonadal fat massQTLWang et al. (2006)
  • a The proportion of variance attributable to the main or interaction effect of the covariate, with “—” representing cases where this figure was not reported.

  • b The proportion of variance is given as the partial ω2-statistic.