TABLE 1

Mutations causing different types of melanotic masses

Type of melanotic phenotype
MutationGene name, function, referencesHaGutbOthercUniqued
skpAG0037skpA, chromatin condensation, cell cycle, Peter et al. (2002); Murphy (2003)+
skpAG0389+
pr-Set720pr-set7, histone H4 methylation, chromatin structure, cell cycle, Karachentsev et al. (2005)++
pr-set7P{hsneo}1/Df(3R)red3l−/+
Su(var)20502/Df(2L)TE29Aa-11Supressor of variegation, chromatin structure cell cycle, Bushey and Locke (2004); Norwood et al. (2004)+
Su(var)20502/Su(var)20504+
Su(var)20504/Df(2L)TE29Aa-11+
dronc2/dronc51dronc or Nc, Nedd2-like caspase, programmed cell death, Laundrie et al. (2003); Chew et al. (2004); Xu et al. (2005)+++
dronc2/Df(3L)AC1++
Dcp-1k05606Death caspase-1, programmed cell death, also affect pita gene, Laundrie et al. (2003)+
Dcp-102132+
Dcp-1k05606/Df(2R)or-BR6+
Arkk11502Apaf-1-related killer, caspase activator, programmed cell death, Rodriguez et al. (1999, 2002); Zhou et al. (1999); Zimmermann et al. (2002)++
Arkk11502/Df(2R)BSC49/+
Df(2R)P803-D1/Arkk11502+
dpldk08815adappled, homolog of C. elegans lin-41, Rodriguez et al. (1996)+
dpldk08815a/Df(2R)ST1+
mxc22a-6/Ymulti sex comb, tumor suppressor, larval hematopoiesis, Santamaria and Randsholt (1995); Saget et al. (1998); Remillieux-Leschelle et al. (2002)+
hopTum/+Hopscotch, Janus kinase, Jak-STAT signaling, Harrison et al. (1995); Luo et al. (2002)+
l(3)mbnE1malignant blood neoplasm, Konrad et al. (1994)+
l(3)mbnE1/++
cact A2cactus, IκB homolog, Rel pathway, Roth et al. (1991); Belvin et al. (1995); Qiu et al. (1998)+++
cactA2/cactE10R01+++
cactG8+++
cact1+++
Toll10B/+Toll, transmembrane receptor, Rel pathway, Gerttula et al. (1988)+
Toll3/++
zfrp8M-1-1zinc finger RP8, homolog of mammalian PDCD2 (programmed cell death 2), Minakhina et al. (2003); S. Minakhina (unpublished results)+
zfrp8M-1-1/Df(2R)SM183+
spagk12101spaghetti, TPR-protein intaracting with Hsp90, Marhold (2000)+
  • a Melanotic nodules found in the hemocoel or in association with Hemese-positive lymph glands.

  • b Gut melanization not accompanied by tissue overgrowth and hemocyte encapsulation.

  • c Melanizations found in other tissues, such as the trachea and salivary glands.

  • d Unique melanotic mass-type-containing variable tissues.