TABLE 6

Suppression of the let-23 vulvaless phenotype

Ave. no. vulval fates (±SE, n)
let-23(+)let-23(sy97)
+3.0 (many)0 (±0, 36)
New mutationlin-65(n3441)3.0 (±0, 35)a0 (±0, 30)
lin(n3628)3.0 (±0, 37)aLetd
mep-1(n3703)3.01 (±0.01, 40)aLetd
ark-1(n3701)3.0 (±0, 33)a0.10 (±0.05, 34)
gap-1(ga133)3.02 (±0.02, 32)a3.0 (±0, 26)
sli-1(n3538)3.0 (±0, 25)a3.0 (±0, 31)
Class Alin-15A(n767)3.0 (±0, 24)b0 (±0, 21)
lin-38(n751)3.0 (±0, 27)bND
Class Blin-15B(n744)3.0 (±0, 20)a0.23 (±0.08, 26)
lin-35(n745)3.0 (±0, 48)a0.20 (±0.06, 38)
Class Cmys-1(n3681)3.06 (±0.03, 36)c1.47 (±0.15, 31)
trr-1(n3712)3.10 (±0.03, 89)b0.28 (±0.07, 46)
  • mep-1(n3703) homozygotes were recognized as the non-Unc progeny of mep-1(n3703)/nT1 n754 heterozygous parents or the sterile progeny of mep-1(n3703)/dpy-20(e1282) unc-30(e191) heterozygous parents. trr-1(n3712) homozygotes were recognized as the non-Gfp progeny of trr-1(n3712) / mIn1[dpy-10(e128) mIs14] heterozygous parents. let-23(sy97) was marked with unc-4(e120), and let-23(sy97) homozygotes were recognized as the Unc non-Gfp progeny of let-23(sy97) unc-4(e120)/mIn1[dpy-10(e128) mIs14] heterozygous parents. ND, not determined because of linkage of these mutations.

  • a These data are from Table 1.

  • b These data are from Table 1 of Ceol and Horvitz (2004).

  • c These data are from Table 3 of Ceol and Horvitz (2004).

  • d Because of the lethality of these animals, we measured the abilities of lin(n3628) and mep-1(n3703) to suppress the Vul phenotype caused by sy10, a let-23 allele that is weaker than sy97. lin(n3628) and mep-1(n3703) were unable to suppress the Vul phenotype of let-23(sy10): lin(n3628); let-23(sy10) double mutants averaged 0.11 vulval fates (n = 27), let-23(sy10); mep-1(n3703) double mutants averaged 0.06 vulval fates (n = 24), and let-23(sy10) single mutants averaged 0.14 vulval fates (n = 21).