TABLE 1

Estimates of QTL positions, effects, and interactions for both backcross experiments

CrossChromosomeQTL namePosition2-LOD support intervalaLODEstimated effectc% of parental differencedCandidate genese
D. sechellia backcross247C25F–60F2.7−0.53 (0.19)7 (3)
94 cM, 5050 genes
378C70E–83E12.5−1.28 (0.16)18 (2)gig, gnu, l(3)80Fi, M(3)82B-C, polo, Rheb, rpr
17 cM, 1400 genes
D. simulans backcross259C52C–60F8.5−0.36 (0.06)5 (1)amz, Ark, Cdk4, Egfr, gbb, M(2)53, M(2)58F
31.5 cM, 1600 genes
33a82C75F5–83A28.2b0.15 (0.10)−2 (1)gig, l(3)80Fi, M(3)82B-C, polo
5 cM, 650 genes
33b93D93F1–90D29.2b−0.36 (0.09)5 (1)cdc2c, E2f, InR, PI3K, sqz
10.8 cM, 400 genes
33a + 3b5.5−0.88 (0.07)12 (1)
  • a Cytological intervals are given in D. melanogaster cytological units. Note that the D. simulans/D. sechellia hybrid genetic map is larger than the D. melanogaster map. The 2-LOD support interval of QTL3a and QTL3b is based on two-dimensional scans in a model including the QTL on chromosome 2 (Figure 4).

  • b The LOD of QTL3a and QTL3b include the interaction term.

  • c The effect of substituting one D. simulans allele with a D. sechellia allele is given in number of ovarioles with SE in parentheses.

  • d SE is given in parentheses.

  • e Candidate genes involved in cell proliferation or cell death were found with the FlyBase Genes Query Tool.