TABLE 2

Suppressors of the hta1-300 increase-in-ploidy phenotype

Gene nameORF size (bp)mTn3-lacZ-LEU2 insertion siteProteinFunction
HHT141173Histone H3Chromatin
MKS11755664Mks1pRegulation of the retrograde pathway
PLO1/HDA319681644Subunit of Hda1 complexUnknown/necessary for HDA activity
PLO1/HDA319681542Subunit of Hda1 complexUnknown/necessary for HDA activity
PLO2/HDA220251638Subunit of Hda1 complexUnknown/necessary for HDA activity
HDA121211938Subunit of Hda1 complexHistone deacetylase activity (H2B, H3)