TABLE 4

Comparison of gene-targeting frequencies

Mutants as % of progeny
Female germlineMale germline
TargetReferencehsTHRNHEJHRNHEJ
Intact targets
yRong and Golic (2000a)38°0.20.01
pugRong and Golic (2001)38°0.020.006
yGong and Golic (2003)38°0.26, 0.12
Cleaved targets
yBibikova et al. (2003)35°0.390.151.40.8
yThis study37°7.01.93.61.0
ryThis study37°15.010.04.29.8
38°9.014.01.37.6