TABLE 2

Effects of C3H (C) and B6 (B) alleles in different QTL on atherosclerosis, plasma lipids, and body weight in the B6.apoE−/− and C3H.apoE−/− intercross

TraitPeak markerBBBCCCP-value
LesionD9mit156178,359 ± 13,867172,756 ± 10,143105,825 ± 9,1607.6 × 10−5
D11mit236196,644 ± 14,310150637 ± 9,138135,065 ± 13,4374.0 × 10−3
LDL/VLDLD1mit270691.1 ± 23.9815.5 ± 20.8911.9 ± 36.81.9 × 10−6
D5mit95767.6 ± 32.5780.3 ± 18.9860.4 ± 37.74.1 × 10−3
D9mit115726.3 ± 24.1826.2 ± 22.4832.5 ± 31.71.8 × 10−3
HDLD1mit27024.4 ± 2.135.0 ± 2.842.5 ± 4.21.7 × 10−3
D3mit4231.3 ± 2.630.6 ± 2.745.0 ± 4.33.9 × 10−3
TriglycerideD1mit270152.3 ± 4.6178.2 ± 4.5185.5 ± 7.22.1 × 10−4
D8mit41161.6 ± 5.3167.8 ± 4.1190.5 ± 6.41.0 × 10−3
Body weightD1mit42521.7 ± 0.526.0 ± 0.426.0 ± 0.72.2 × 10−9
D1mit20621.6 ± 0.525.8 ± 0.426.0 ± 0.71.0 × 10−8
D4mit25123.0 ± 0.624.7 ± 0.426.3 ± 0.72.5 × 10−3
D14mit18524.3 ± 0.525.8 ± 0.623.5 ± 0.57.8 × 10−3
D17mit18027.3 ± 0.924.1 ± 0.424.2 ± 0.61.6 × 10−4
  • Measurements are given as means ± SD. The units for these measurements are: Lesion (square micrometers per section), LDL/VLDL cholesterol (milligrams per deciliter), HDL cholesterol (milligrams per deciliter), triglyceride (milligrams per deciliter), and body weight (g). BB, homozygous for C57BL/6-derived alleles of the linked marker; CC, homozygous for C3H alleles of the linked marker; BC, heterozygous for C57BL/6-derived and C3H alleles of the linked marker.