Significant and suggestive QTL for atherosclerotic lesions, plasma LDL/VLDL cholesterol, HDL cholesterol, triglyceride, and body weight identified in the B6.apoE−/− and C3H.apoE−/− intercross
| Chromosome marker(cM)a | SIΔ (cM)c | Variance (%)d | Model of inheritancee | Overlapping QTLf | ||||
|---|---|---|---|---|---|---|---|---|
| Trait | LODb | P-value | Name | Reference | ||||
| D9mit156(42) | Lesion | 4.1 | 37–50 | 34 | 0.00008 | Dominant/B6 | ||
| D11mit236(20) | Lesion | 2.4 | 11–33 | 5 | 0.00361 | Dominant/C3H | ||
| D1mit270(92.3) | LDL/VLDL | 6.3 | 88–97 | 32 | 0.00001 | Additive | Cq2, Hdlq15 | Machleder et al. (1997) |
| D5mit95(68) | LDL/VLDL | 2.2 | 51–81 | 4 | 0.00604 | Dominant/B6 | Unnamed QTL | Machleder et al. (1997) |
| D9mit115(56) | LDL/VLDL | 2.5 | 51–65 | 5 | 0.00323 | Dominant/C3H | Cq4, Cq5 | Suto et al. (2003) |
| D1mit270(92.3) | HDL | 3.0 | 81–105 | 20 | 0.00110 | Additive | Hdlq15 | Machleder et al. (1997) |
| D3mit42(58.8) | HDL | 2.3 | 50–67 | 5 | 0.00282 | Dominant/B6 | Unnamed QTL | Mehrabian et al. (2000) |
| D1mit270(92.3) | Triglyceride | 3.8 | 78–97 | 13 | 0.00642 | Dominant/C3H | Cq2 | Suto et al. (1999) |
| D8mit41(41) | Triglyceride | 3.2 | 33–51 | 10 | 0.00067 | Dominant/B6 | Tgq2 | Shike et al. (2001) |
| D1mit425(81.6) | Weight | 9.0 | 74–87 | 40 | 0.00001 | Dominant/C3H | BW17 | Anunciado et al. (2000) |
| D1mit206(95.8) | Weight | 8.3 | 88–101 | 34 | 0.00060 | Dominant/C3H | BW8q1 | Zhang et al. (2003) |
| D4mit251(66) | Weight | 2.7 | 39–66 | 15 | 0.00217 | Additive | BW7 | Brockmann et al. (2000) |
| D14mit185(54) | Weight | 2.2 | 44–61 | 4 | 0.00726 | Additive | Bwnd2wk7 | Brockmann et al. (2004) |
| D17mit180(29.4) | Weight | 3.4 | 19–35 | 7 | 0.00039 | Dominant/C3H | Wt3q3 | Moody et al. (1999) |
↵a From Mouse Genome Informatics database at http://www.informatics.jax.org.
↵b LOD scores were derived by dividing the LRS by 4.6. Suggestive QTL LOD ≥ 2.3 and significant QTL LOD ≥ 3.3 for lesion size; suggestive QTL LOD ≥ 2.3 and significant QTL LOD ≥ 3.4 for LDL/VLDL; suggestive QTL LOD ≥ 2.3 and significant QTL LOD ≥ 3.3 for HDL-C; suggestive QTL LOD ≥ 2.3 and significant QTL LOD ≥ 3.2 for triglyceride; suggestive QTL LOD ≥ 2.4 and significant QTL LOD ≥ 3.4 for body weight as defined by 1000 permutation tests. The significant loci are underlined to easily distinguish them from suggestive loci.
↵c SI, support intervals, were defined by a 1-unit decrease in LOD score on either side of the peak marker.
↵d Variance (%) indicates the percentage of the total phenotypic variance detected in the F2 cohort with which each marker showing linkage was associated.
↵e Model of inheritance was determined using the MapManager QT program.
↵f Overlapping QTL identified in previous studies.