TABLE 2

SNPs associated with the reproductive performance phenotype

StrainD11Spn173D11Spn129Paternal alleleSNP
123456789101112Referencea
BSdomesticus?INDNDNDNDNDNDNDNDNDNDNDNDWakasugi and Morita (1977)
NCdomesticus?INDNDNDNDNDNDNDNDNDNDNDNDWakasugi et al. (1967)
AdomesticusICTTATTGGGAGAThis study
DBA/2domesticusICTTATTGGGAGAThis study
BALB/cdomesticusICTTATTGGGAGAThis study
C57BL6domesticusICTTATTGGGAGAThis study
129X1domesticusICTTATTGGGAGAThis study
PERAdomesticusICTTATTGGGAGAThis study
RBAdomesticusICTTATTGGGAGAThis study
CBAbdomesticusINDNDNDNDTTNDGGAGNDMann (1986)
C3HbdomesticusINDNDNDNDTTGGGAGABuehr et al. (1987); Leclerc et al. (1994); this study
KKbdomesticusINDNDNDNDACAAAAGGWakasugi et al. (1967)
LEWESdomesticusICTTAACAAAAGGThis study
PWKbmusculusCCTTAACAAAGTGJiri Forejt (personal communication)
SKIVEmusculusCCTTAACAAAGTGThis study
WSBbdomesticusCNDNDNDNDNDNDNDNDNDGTGThis study
DDKdomesticusCAACGdeldeldeldeldelGTGThis study
MOLCcastaneusCAACGACAAAGTGThis study
PANCEVOM. spicilegusCAACGACAAAGTGThis study
CASTcastaneusCAACGACAAAGTGThis study
TIRANOdomesticusCAACGACAAAGTGThis study
ZALENDEdomesticusCAACGACAAAGTGThis study
JF1castaneusCAACGACAAAGTGThis study
PERCdomesticusCAACGACAAAGTGThis study
MOMmolossinusCNDNDNDNDNDNDNDNDNDNDNDNDZhao et al. (2002)
CASPcastaneusCNDNDNDNDNDNDNDNDNDNDNDNDZhao et al. (2002)
  • The table provides the strain name, phylogenetic origin of the haplotype in the candidate interval for the paternal gene defined by progeny testing and whether the allele at the paternal gene is incompatible (I) or compatible (C) with the maternal DDK factor. In addition, the table provides the allele present in each strain at each of the 12 SNPs with the highest level of association with the DDK syndrome phenotype. The alleles at the two SNPs that are most strongly associated with phenotype are underlined. The positions of the SNPs are as follows: 1, 82734817; 2, 82734820; 3, 82735318; 4, 82735343; 5, 82833126; 6, 82833146; 7, 82833386; 8, 82833571; 9, 82833572; 10, 82843176; 11, 82843476; 12, 82857766. The phylogenetic origin of the haplotypes in wild-derived strains is shown as reported previously (http://www.jax.org, Ideraabdullah et al. 2004). The phylogenetic origin of the haplotypes in hybrid strains and classical strains was determined on the basis of the diagnostic alleles shown in supplemental Table 3 at http://www.genetics.org.supplemental/. del, deletion.

  • a References support the assigment of the paternal allele.

  • b Additional strains used to test whether SNP-10 and SNP-11 predict the reproductive performance.