TABLE 3

Mutations found in representative suppressors

AlleleBase substitutionAmino acid replacements
srb7-1G265TE89a
rox3-102G405AW135a
sin4-111G383AG128D
G1836TE612D
sin4-133tsG721AA241T
G1836TE612D
srb9-92675: deletion of TL892YFPLSIDa
srb10-27768: deletion of GM257a
  • The E612D amino acid substitution identified in both sin4 alleles was traced back to the parent strain, which is phenotypically SIN4.

  • a Termination codon.