TABLE 5

Loci interaction in RA-induced forelimb defects in BC1 fetuses

Locus 1Locus 2TraitJoint
 LODaLocus 1
 LODa,bLocus 2
 LODa,bEpistasis
 LODaLocus 1
 P-valuecLocus 2
 P-valuecInteraction
 P-valuec
Chr11 D11Mit39Chr18 D18Mit64All-1 9.87.30.12.4<0.0001NS0.006
Pre-1 5.73.90.01.7<0.0001NS0.03
Post-1 6.74.90.11.8<0.0001NS0.01
Right-110.48.00.12.4<0.0001NS0.003
QT-1 6.74.90.01.7<0.0001NS0.009
  • a Results are from Map Manager QTX using interaction, χ2 test, P = 1.0 × 10−5.

  • b Locus 1 and locus 2 LOD scores were calculated by single-marker analysis using additive regression model.

  • c Results were generated by SAS program. For binary traits, logistic regression was used; for semiquantitative trait, two-way ANOVA was used. NS, nonsignificant.