TABLE 1

Reproductive and selected-malformation percentages for backcross fetuses treated on GD 9.25 with 75 mg of RA per kilogram of body weight

CrossTotal no.
 of littersTotal no. of
 implants/collected
 fetusesaMean litter %
 of resorptionsbMean litter %
 forelimb
 defectsbMean litter %
 hindlimb
 defectsbMean litter %
 cleft palateb
C57♀ × F1101 831/419c49.7 (±3.5)28.2 (±3.1)d3.2 (±1.8)27.5 (±3.3)d
F1♀ × C57♂ 911020/569e44.0 (±3.8)38.5 (±3.7)d0.6 (±0.4)37.6 (±2.8)d
  • a Collected fetuses included dead fetuses.

  • b Parenthetical value represents the standard error of the mean.

  • c Thirteen of 419 fetuses were not genotyped due to the poor quality of isolated DNA.

  • d Mean percentage significantly different between crosses, t-test, P < 0.05.

  • e Twenty-four of 569 fetuses were not genotyped due to the poor quality of isolated DNA.