TABLE 1

Haplotype-based tests of the neutral coalescent

TestQuantity on which
 test is basedReference for theoretical
 predictions about quantityReference for test
Ewens-Watterson homozygosity testℙ(F|K, n)Ewens (1972); Watterson (1977)Watterson (1977)(1978)
Exact test conditional on Kℙ(C|K, n)Ewens (1972)Slatkin (1994)(1996)
Hudson et al. haplotype test
   (HHT)ℙ(M|S, n, θ)This articleHudson et al. (1994)
Haplotype no. test (HNT)ℙ(K|S, n, θ)Griffiths and Tavaré (1996);
   this articleDepaulis and Veuille (1998);
   Depaulis et al. (2001);
   Markovtsova et al. (2001);
   Wall and Hudson (2001)
Haplotype diversity test (HDT)ℙ(H|S, n, θ)This articleDepaulis and Veuille (1998);
   Depaulis et al. (2001);
   Markovtsova et al. (2001);
   Wall and Hudson (2001)
Haplotype configuration
   test (HCT)ℙ(C|S, n, θ)This articleThis article
  • Additional haplotype tests are discussed by Fu (1996, 1997), Kreitman (2000), and Sabeti et al. (2002). Fu (1998) provides a related but not haplotype-based test that uses the configuration of segregating sites in the sample.