TABLE 1

Molecular and phenotypic characteristics of extant fritz alleles

AlleleOriginal
 nameMutagenSourcePhenotypeMutationProtein product
fritz1EMSLancasterStrongTAT > TAA in exon 3Tyr506 > STOP
fritz2UnknownCambridgeStrongAAA > TAA in exon 3Lys558 > STOP
fritz3GJ66/78X rayCambridgeWeak, temperature
 sensitiveGAC > CAC in exon 3Asp375 > Ala (see Figure 7A)
fritz7GJ66/11X rayCambridgeStrong, reduced
 viability/fertility1329-nt deletion
 upstream from nt − 11
 (see Figure 5A)Wild Type
fritz26fy-twinEMSVirginiaWeakNDND
fritz27FK1172X rayVirginiaStrongAAG > ATG in exon 5Lys783 > Met
fritz28FK1521X rayVirginiaStrong8 nt replaced by 9 nt in exon 3: TGCGGCTG
 CAGC > TGTCCGT
 CATTGCN-terminal 472 + 39 novel aa
fritz29FK4211X rayVirginiaStrong96-nt deletion in exon 3Deletion Gln352 to Leu385
fritz30FK3521X rayVirginiaStrong7-nt deletion in exon 3: CATGTGCCTGA > CAGA (plus independent ∼1 kb deletion downstream)N-terminal 493 + 7 novel aa
fritz33FK55a11X rayVirginiaStrong1-nt insertion in exon 3: GATCTGCT > GATCCTGCTN-terminal 309 + 37 novel aa
  • EMS, ethyl methanesulfonate; nt, nucleotide; ND, not determined.