TABLE 1

Activity of CBP variants

DriverRespondernej+nej3/+Activity
GMR-GAL4UAS-CBP FLSevere rough eyeSuppressGain of function
GMR-GAL4UAS-CBP ΔNZKModerate rough eyeEnhanceDominant negative
GMR-GAL4UAS-CBP ΔBHQSevere rough eyeEnhanceDominant negative
GMR-GAL4UAS-CBP ΔHQMild rough eyeNo effect?
sev-GAL4UAS-CBP ΔQSevere rough eyeNo effect?
GMR-GAL4UAS-CBP KIXVery mild rough eyeSuppressGain of function
DriverResponderPhenotypeUAS-ciUAS-MadUAS-panTCF
GMR-GAL4UAS-CBP FLSevere rough eyeNo effect  Enhance No effect
GMR-GAL4UAS-CBP ΔNZKModerate rough eyeNA  Enhance Enhance
GMR-GAL4UAS-CBP ΔBHQSevere rough eyeNo effect  NA NA
GMR-GAL4UAS-CBP ΔHQMild rough eyeNo effect  NA NA
GMR-GAL4UAS-CBP ΔQSevere rough eyeNo effect  Enhance No effect
  • NA, not applicable.