TABLE 1

Calculations of mutable sites

TotalA·TG·C
Fraction of transmitted substitutions1.000.820.18
Substitution rate1.04 × 10−61.479 × 10−64.440E × 10−7
Autosomal sites/genomea2.35 × 1091.36 × 1099.87 × 109
Substitutions/gamete2,4572,017438
Substitution homozygotes/G1 family1,9651,613351
Substitutions screened2,036,1921,671,470363,358
Ataxics observed/gamete0.0106NANA
Ataxics generated/gamete0.01330.01090.0024
Substitutions/ataxic185,108185,307183,514
Ataxic sites/genome (0 degeneracy)12,7017,3585,381
Ataxic sites/genome (twofold degeneracy)19,05111,0388,071
Inner ear observed/gamete0.0058NANA
Inner ear generated/gamete0.00720.00590.0013
Substitutions/inner ear phenotype339,365339,730336,443
Inner ear sites/genome (0 degeneracy)6,9284,0142,935
Inner ear sites/genome (twofold degeneracy)10,3916,0214,402
  • a Number of autosomal sites taken from Waterston et al. (2002).