TABLE 7

Accuracy of estimation of the parameters for the distribution of a quantitative phenotype in the analysis of simulated six-locus data for the SAA1 gene

SamplebEstimatedb
Populationa
 (μ1, μ2, σ)NMean 1Mean 2SDμ̂1 ± SEμ̂2 ± SEσ̂ ± SEP-valuesb
(160, 160, 5.0)b 100159.33159.655.178159.20 ± 0.80159.72 ± 0.695.174 ± 0.3120.637
 200159.88159.365.164159.87 ± 0.70159.36 ± 0.445.164 ± 0.2390.517
 400159.51159.984.855159.39 ± 0.40160.05 ± 0.304.851 ± 0.1430.194
1000159.94160.104.884159.95 ± 0.26160.09 ± 0.194.884 ± 0.1130.642
(161, 160, 5.0) 100159.99160.445.229160.16 ± 0.88160.34 ± 0.675.233 ± 0.3290.870
 200160.99160.124.737160.95 ± 0.55160.13 ± 0.474.739 ± 0.2340.220
 400160.65159.994.781160.63 ± 0.40160.02 ± 0.304.782 ± 0.1700.209
1000160.77159.845.056160.78 ± 0.27159.84 ± 0.205.055 ± 0.1150.00345
(163, 160, 5.0) 100162.81160.494.915162.90 ± 0.79160.51 ± 0.634.911 ± 0.3500.0219
 200162.55159.905.235162.50 ± 0.59159.87 ± 0.495.236 ± 0.2850.000794
 400163.20159.835.188163.06 ± 0.39159.95 ± 0.345.229 ± 0.2056.47 × 10−9
1000162.76159.894.873162.65 ± 0.25159.98 ± 0.204.900 ± 0.1092.90 × 10−17
(165, 160, 5.0) 100165.15159.235.178165.04 ± 0.90159.30 ± 0.645.227 ± 0.3195.58 × 10−7
 200164.47159.174.541164.26 ± 0.50159.27 ± 0.444.623 ± 0.1893.95 × 10−13
 400164.98160.035.021164.95 ± 0.42160.09 ± 0.315.047 ± 0.1711.72 × 10−19
1000164.89160.114.957164.81 ± 0.24160.19 ± 0.204.996 ± 0.1129.62 × 10−44
  • a The conditions of the simulations were the same as in Table 6 except for the following two points: the haplotype frequencies (Θ) obtained from the six-locus data of the SAA1 gene (see Table 1) were used and the ACCGTC haplotype was assumed to be the phenotype-associated haplotype.

  • b The methods for the calculations of the values in these categories are the same as those in Table 6.

  • A sample of size N was obtained by the simulation using a set of given parameters, and the data obtained were analyzed, after removing the phase information, using QTLHAPLO for both the estimation of parameters and the test of the association between the presence of a haplotype and the quantitative phenotype.