TABLE 2

Estimated haplotype frequencies for the CAPN10 gene

HaplotypeaFrequencybFrequency under
 linkage equilibriumc
1210.56960.4285
1120.25880.0974
1110.10780.2557
2210.04680.0250
1220.00870.1632
2120.00700.0057
2220.00120.0095
  • a Haplotype involving the three SNP sites within the CAPN10 gene.

  • b The haplotype frequencies Θ were estimated from the genotype data by assuming the presence of the linkage disequilibrium using QTLHAPLO.

  • c The haplotype frequencies Θ were estimated from the genotype data by assuming the linkage equilibrium. Note that the frequencies of a haplotype are expressed as the product of the allele frequencies in the case of linkage equilibrium.

  • Genotypes were determined at three SNP sites in the CAPN10 gene in 281 diabetic subjects. These three SNP sites have been reported to be associated with the development of type II diabetes (Horikawa et al. 2000). Using the genotype but not the phenotype data in 281 subjects, the haplotype frequencies were estimated by QTLHAPLO using only the genotype data.