TABLE 10

Estimated parameters and empirical type I error rates for analysis of the simulated data under the null hypothesis

Θμ1 = μ2Sample size NNo. of
 samplesμ̂1a (mean ± SD)μ̂2a (mean ± SD)σ̂a (mean ± SD)Type I
 error rate
Four-locus model160 10010,000160.01 ± 0.753160.01 ± 0.6764.936 ± 0.3530.0496
Four-locus model160100010,000160.00 ± 0.237160.00 ± 0.2134.995 ± 0.1120.0514
Six-locus model160 10010,000160.00 ± 0.822159.99 ± 0.6354.933 ± 0.3520.0606
Six-locus model160100010,000160.00 ± 0.256160.00 ± 0.2014.994 ± 0.1100.0541
  • a Mean ± SD of the estimates for parameters of the distribution of the quantitative phenotype obtained by the analysis.

  • Each simulation was performed under the null hypothesis, μ1 = 160, μ2 = 160, σ = 5, with N = 100 or 1000. Every simulation was repeated 10,000 times for each condition.